{"product_id":"tirzepatide","title":"Tirzepatide","description":"\u003cp\u003eTirzepatide is a synthetic 39-amino acid peptide engineered from the native GIP sequence with incorporated GLP-1 receptor activity. It is the first dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist — a class referred to in the literature as a \"twincretin.\"\u003c\/p\u003e\n\u003cp\u003eThe compound features two non-coded α-aminoisobutyric acid (Aib) residues at positions 2 and 13 that confer resistance to DPP-4 enzymatic degradation, and a C20 fatty diacid moiety conjugated to Lys20 via a γGlu-2×OEG linker, enabling extended plasma half-life through albumin binding (~5 days). The C-terminus is amidated.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eDual incretin receptor signaling and downstream pathway analysis (GIP\/GLP-1)\u003c\/li\u003e\n\u003cli\u003eIn-vitro models of glucose-dependent insulin secretion and glucagon suppression\u003c\/li\u003e\n\u003cli\u003eMetabolic pathway research involving lipid metabolism and energy homeostasis\u003c\/li\u003e\n\u003cli\u003eReceptor binding affinity and selectivity studies (GIPR vs. GLP-1R)\u003c\/li\u003e\n\u003cli\u003eStructural biology and cryo-EM investigations of peptide–receptor complexes\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003ePublished Research Context\u003c\/h3\u003e\n\u003cp\u003eTirzepatide has been the subject of extensive preclinical and structural research. Cryo-EM studies (Sun et al., 2022) have resolved the peptide bound to both GLP-1R and GIPR in complex with G-proteins, revealing distinct interaction networks including ionic bonds, hydrogen bonding, and hydrophobic contacts at the receptor interfaces. The compound's 14 unique amino acid substitutions (relative to native GLP-1) and its dual receptor engagement mechanism make it a significant tool for studying multiplexed pharmacological signaling.\u003c\/p\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C225H348N48O68\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 4,813.53 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSequence Length:\u003c\/strong\u003e 39 amino acids\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 2023788-19-2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e White lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Lyophilized, −20°C, protected from light\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% by HPLC\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003e⚠ For in-vitro research use only. Not for human consumption. Not FDA approved. Certificate of Analysis included with every order.\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e🔬 Research Reference:\u003c\/strong\u003e \u003ca href=\"\/pages\/tirzepatide\"\u003eTirzepatide — Compound Reference \u0026amp; Research Data\u003c\/a\u003e  |  \u003ca href=\"\/pages\/copy-of-copy-of-copy-of-copy-of-copy-of-coa-tirzepatide\"\u003eCertificate of Analysis (Lot 2603)\u003c\/a\u003e\u003c\/p\u003e\n","brand":"peplix","offers":[{"title":"1 Vial","offer_id":46486291513534,"sku":null,"price":59.0,"currency_code":"USD","in_stock":true},{"title":"5 Vials","offer_id":46486291546302,"sku":null,"price":295.0,"currency_code":"USD","in_stock":true},{"title":"10 Vials","offer_id":46486291579070,"sku":null,"price":590.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0755\/3817\/0046\/files\/tirzepatide_800_f2a2c363-a88e-45ff-8ff3-6c0d42fdf9b6.png?v=1773326182","url":"https:\/\/peplix.myshopify.com\/products\/tirzepatide","provider":"peplix","version":"1.0","type":"link"}