{"product_id":"tb-500","title":"TB-500","description":"\u003cp\u003eTB-500 is a synthetic analogue of Thymosin Beta-4 (Tβ4), an endogenous 43-amino acid peptide encoded by the TMSB4X gene. It is the most abundant member of the beta-thymosin family and functions as the principal actin-sequestering molecule in most eukaryotic cell types. Intracellular concentrations can reach up to 0.5 mM, reflecting its fundamental role in cytoskeletal regulation.\u003c\/p\u003e\n\u003cp\u003eThe peptide forms a 1:1 complex with G-actin (globular actin), opposing polymerization into F-actin (filamentous actin) and effectively buffering the monomeric actin pool. The conserved LKKTET motif at positions 17–22 is frequently cited as the primary actin-binding domain, though crystallographic modeling shows that essentially the entire length of the sequence interacts with actin in the complex. TB-500 does not bind to the extracellular matrix and has a low molecular weight, allowing it to travel through tissues efficiently.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eActin polymerization dynamics and cytoskeletal remodeling studies\u003c\/li\u003e\n\u003cli\u003eCell migration, morphology, and motility assays\u003c\/li\u003e\n\u003cli\u003eAngiogenesis research — identified as a gene upregulated 4–6 fold during early blood vessel formation\u003c\/li\u003e\n\u003cli\u003eEpicardial progenitor cell activation and cardiac remodeling models\u003c\/li\u003e\n\u003cli\u003eAnti-inflammatory pathway investigation (oxidized Tβ4 sulfoxide derivative)\u003c\/li\u003e\n\u003cli\u003eWound fluid composition analysis and extracellular matrix signaling\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003ePublished Research Context\u003c\/h3\u003e\n\u003cp\u003eThymosin Beta-4 was originally isolated from calf thymus and was the second peptide from Thymosin Fraction 5 to be fully sequenced and synthesized. Its role extends well beyond immune function: research at multiple institutions has demonstrated diverse effects in tissue regeneration models. Phase 2 clinical trials in patients with pressure ulcers, venous ulcers, and epidermolysis bullosa showed accelerated repair rates with favorable safety profiles. Notably, Glasgow University researchers (1999) identified the Tβ4 sulfoxide derivative as having multiple anti-inflammatory effects on neutrophils, including reduced adhesion to endothelial cells. The peptide is highly conserved across mammalian species, underscoring its fundamental biological significance.\u003c\/p\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C212H350N56O78S\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 4,963 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSequence Length:\u003c\/strong\u003e 43 amino acids\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGene:\u003c\/strong\u003e TMSB4X\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eKey Motif:\u003c\/strong\u003e LKKTET (positions 17–22)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e White lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Lyophilized, −20°C, desiccated\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% by HPLC\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003e⚠ For in-vitro research use only. Not for human consumption. Not FDA approved. Certificate of Analysis included with every order.\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e🔬 Research Reference:\u003c\/strong\u003e \u003ca href=\"\/pages\/tb-500\"\u003eTB-500 — Compound Reference \u0026amp; Research Data\u003c\/a\u003e  |  \u003ca href=\"\/pages\/copy-of-copy-of-copy-of-coa-tb500\"\u003eCertificate of Analysis (Lot 2603)\u003c\/a\u003e\u003c\/p\u003e\n","brand":"peplix","offers":[{"title":"1 Vial","offer_id":46486298951870,"sku":"PLX-TB500-5MG-1","price":52.0,"currency_code":"USD","in_stock":true},{"title":"5 Vials","offer_id":46486298984638,"sku":"PLX-TB500-5MG-2","price":195.0,"currency_code":"USD","in_stock":false},{"title":"10 Vials","offer_id":46486299017406,"sku":"PLX-TB500-5MG-3","price":403.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0755\/3817\/0046\/files\/tb500_800_23aad1ad-473f-4549-86ba-944cb91ac2bf.png?v=1773325961","url":"https:\/\/peplix.myshopify.com\/products\/tb-500","provider":"peplix","version":"1.0","type":"link"}