{"product_id":"epithalon","title":"Epithalon","description":"\u003cp\u003eEpithalon (also spelled Epitalon) is a synthetic tetrapeptide with the amino acid sequence Ala-Glu-Asp-Gly (AEDG). It was identified as the putative active component of epithalamin, a polypeptide complex originally extracted from bovine pineal gland tissue. The compound was first characterized at the St. Petersburg Institute of Bioregulation and Gerontology and has since become one of the most extensively studied synthetic peptides in telomere biology and cellular aging research.\u003c\/p\u003e\n\u003cp\u003eEpithalon's primary mechanism of interest involves the induction of telomerase activity in somatic cells. In telomerase-negative human fetal fibroblast cultures, the peptide has been shown to reactivate expression of the telomerase catalytic subunit (hTERT), increase enzymatic telomerase activity, and extend telomere length — sufficient to surpass the Hayflick limit, extending proliferative capacity from passage 34 to passage 44. The peptide has also been shown to enter cell nuclei and bind selectively to DNA regions rich in CAG and ATTTC repeats within telomerase gene promoter regions.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eTelomerase activation and hTERT expression studies in somatic cell cultures\u003c\/li\u003e\n\u003cli\u003eTelomere length dynamics and Hayflick limit extension research\u003c\/li\u003e\n\u003cli\u003eChromatin remodeling and epigenetic regulation of aging markers\u003c\/li\u003e\n\u003cli\u003eAlternative Lengthening of Telomeres (ALT) pathway investigation in cancer cell lines\u003c\/li\u003e\n\u003cli\u003eMelatonin secretion and pineal gland function studies\u003c\/li\u003e\n\u003cli\u003eAntioxidant enzyme activity research (SOD, glutathione peroxidase, catalase)\u003c\/li\u003e\n\u003cli\u003eChromosomal stability and antimutagenic effect studies\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003ePublished Research Context\u003c\/h3\u003e\n\u003cp\u003eOver two decades of published research support Epithalon's role as a molecular tool for studying telomere biology. Khavinson, Bondarev, and Butyugov (Bulletin of Experimental Biology and Medicine, 2003) demonstrated telomerase reactivation and telomere elongation in human somatic cells. More recent work (PMC, 2025) provided quantitative data showing dose-dependent telomere extension in normal epithelial and fibroblast cells through hTERT upregulation, while cancer cell lines exhibited telomere extension through ALT activation — suggesting cell-type-dependent mechanisms. Animal studies have demonstrated increased antioxidant enzyme activities, reduced spontaneous tumor incidence, and extended lifespan in rodent models. Human clinical studies have shown significant telomere length increases in blood cells of patients aged 60–80.\u003c\/p\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C14H22N4O9\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 390.35 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSequence:\u003c\/strong\u003e AEDG (Ala-Glu-Asp-Gly)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 307297-39-8\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e White lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Lyophilized, −20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% by HPLC\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003e⚠ For in-vitro research use only. Not for human consumption. Not FDA approved. Certificate of Analysis included with every order.\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e🔬 Research Reference:\u003c\/strong\u003e \u003ca href=\"\/pages\/epithalon\"\u003eEpithalon — Compound Reference \u0026amp; Research Data\u003c\/a\u003e  |  \u003ca href=\"\/pages\/copy-of-copy-of-copy-of-copy-of-copy-of-coa-epithalon\"\u003eCertificate of Analysis (Lot 2603)\u003c\/a\u003e\u003c\/p\u003e\n","brand":"peplix","offers":[{"title":"1 Vial","offer_id":46486295511230,"sku":"PLX-EPTH-5MG-1","price":48.0,"currency_code":"USD","in_stock":true},{"title":"5 Vials","offer_id":46486295543998,"sku":"PLX-EPTH-5MG-2","price":240.0,"currency_code":"USD","in_stock":true},{"title":"10 Vials","offer_id":46486295576766,"sku":"PLX-EPTH-5MG-3","price":480.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0755\/3817\/0046\/files\/epithalon_800_48e6be8d-4992-4cb3-b236-34baf42588e1.png?v=1773325877","url":"https:\/\/peplix.myshopify.com\/products\/epithalon","provider":"peplix","version":"1.0","type":"link"}